Contact

  • Title: Professor
  • Department: Institute of Biochemistry and Molecular Biology
  • Address: 1210 Yifu Biology Building
  • Tel: 09318912428
  • Fax: 09318912428
  • Email: dongsl@lzu.edu.cn
  • Homepage:
Bio

July 2001 – April 2004, Lecturer, School of Life Sciences, Lanzhou University

Nov. 2003 – Nov. 2004, Postdoc, Max-Planck institute of Biochemistry, Germany

May 2004 - April 2012, Associate Professor, School of Life Sciences, Lanzhou University

Mar. 2007 – Sept. 2008, Guest Scientist, Max-Planck institute of Biochemistry, Germany

May 2012- Present, Professor, School of Life Sciences, Lanzhou University

Academic Appointments

Sept. 1991 – June 1995, Bachler, Department of Biology, Lanzhou University

Sept. 1995 – June 1998, Master of Science, Biophysics, Lanzhou University

Sept. 1998 – June 2001, Ph.D, Botany, Lanzhou University

Administrative Appointments

1. Member of Chinese Chemistry Society

2. Member of Chinese Molecular Biology and Biochemistry Society

3. Member of Chinese Physiology Society

4. Member of American Peptide Society

5. Member of Chinese Peptide Society

6. Member of Gansu Physiology Society

 

Honors & Awards

1. Gansu Science and Technology Progress Award (2nd level, 2014, 3/7)

2. Excellent Course of Gansu (2011, 2/3)

3. Longji Award of Youth, Lanzhou University (2010)

4. Youth Scholar Award of Krupps, Germany (2003)

5. Excellent Course of Gansu (2003, 3/3)

6. Course for Biological Science Base of ministry of education (2002, 2/3)

7. Challenge Cup of Gansu Province (1st level, 2002)

8. Appraisal of Scientific and Technological Achievements of the Ministry of Education (2001, 3/7)

9. Gansu Science and Technology Progress Award (3rd level, 2001, 2/10)

10. Gansu Science and Technology Progress Award (2nd level, 1999, 7/10)

Funding

1. Chemistry and Biology of Peptides (including peptide drugs)

2. Molecular Probes

 

Publications

2020
83. Jing Zhang, Chan Ma, Ruijia Wang, Chunbo He, Hailan Li, Shouliang Dong*. Endokinin A/B stimulates rat gastric motility through myogenic NK1 receptors located in fundus. Can. J. Physiol. Pharmacol. 2020, online. DOI: 10.1139/cjpp-2019-0522.
82. 實驗課程中應用MOOC/SPOC的教學模式探索——以動物生理學實驗為例. 馬明,唐曉龍,常民,董守良,陳強. 實驗室研究與探索. 2020, 06, 166-168+206 
81. Zhengkun Liu, Qianqian Wang, Mohui Li, Yujie Ai, Haoxuan Pan, Pengtao Li, Hao Lang, Kunyu Li, Shouliang Dong*. White light emission from single natural molecules: solvatochromic properties of 10-hydroxycamptothecin. Dyes and Pigments. 2020, 180, 108533. DOI: 10.1016/j.dyepig.2020.108533
80. Zhengkun Liu, Qianqian Wang, Hao Wang, Wenting Su, Shouliang Dong*. A FRET Based Two-Photon Fluorescent Probe for Visualizing Mitochondrial Thiols of Living Cells and Tissues. Sensors 2020, 20(6), 1746; https://doi.org/10.3390/s20061746.
79. Zhengkun Liu, Qianqian Wang, Hao Wang, Yuheng Lan, Shouliang Dong*. Quaternary ammonium modified fluorescent probe for hydrogen sulfide detection in living cells. Journal of Photochemistry & Photobiology, A: Chemistry. 2020, 389, 112213. http://doi.org/10.1016/j.jphotochem.2019.112213.

2019
78. Zhengkun Liu, Qianqian Wang, Hao Wang, Wenting Su, Shouliang Dong*. A chloroacetate based ratiometric fluorescent probe for cysteine detection in biosystems. Tetrahedron Letters. 2019, 60(44), 151218. http://doi.org/10.1016/j.tetlet.2019.151218.
77. 馬明, 唐曉龍, 常民, 董守良, 陳強. 淺談如何提高蛙心灌流實驗的教學效果. 實驗室科學, 2019, 22(01): 72-75.
76. Chunbo He, Hailan Li, Jing Zhang, Lanxia Zhou?, Shouliang Dong??. In vitro and in vivo characterization of the bifunctional μ- and δ-opioid receptors ligand MCRT on mouse gastrointestinal motility. Neuropeptides, 2019, 74: 82-87. DOI: 10.1016/j.npep.2019.01.006.

2018
75. 馬明,常民,唐曉龍,董守良,陳強. 動物生理學實驗調查問卷分析. 實驗室科學. 2018, 21(3): 208-212.

2017
74. Xiangdong Cai, Zhao Liu, Sha Zhao, Chen Song, Shouliang Dong* and Jianxi Xiao*. A single stranded fluorescent peptide probe for targeting collagen in connective tissues. ChemComm. 2017.53: 11905-11908. DOI: 10.1039/c7cc06056d.
73. 馬明,唐曉龍,董守良,常民,陳強. 動物生理學實驗課程的定位與改革實踐. 實驗室科學. 2017, 20(3): 84-87.
72. 馬明,盛英卓,董守良,常民,唐曉龍,陳強. 一種輸液針改造的多用途家兔插管. 實用新型專利,已授權(授權日:2017/10/13):ZL201621274454.9
71. 董守良,玄其存,曹碩,常民. 一種布舍瑞林的固液合成方法. 國家發明專利, 已授權(授權日:2017/09/27): ZL201410741975.X.
70. Xu Li,Zhengkun Liu and Shouliang Dong*. Bicyclo[6.1.0]nonyne and tetrazine amino acids for Diels-Alder Reactions. RSC Advances. 2017, 7, 44470-44473. DOI: 10.19/c7ra08136g.
69. Chunbo He, Hailan Li, Jing Zhang, Yanping Kang, Fang Jia, Shouliang Dong*, Lanxia Zhou*. Supraspinal Inhibitory Effects of Chimeric Peptide MCRT on Gastrointestinal Motility in Mice. Journal of Pharmacy and Pharmacology. 2017, 69, 1244-1251. doi: 10.1111/jphp.12761.
68. 董守良, 曹碩, 李兆亮, 葛鑫. 一種地加瑞克的固相合成方法. 國家發明專利, 已授權(授權日期:2017/02/21): ZL201410211655.3.

2016
67. Jing Zhang, Chunbo He, Xiong Pi, Yan Wang, Lanxia Zhou*, Shouliang Dong*. MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin A/B. European Journal of Pharmacology. 2016, 792, 33-37. DOI: 10.1016/j.ejphar.2016.10.028.
66. S. Cao, Q. Jin, L.Geng, L. Mu and S. Dong*, A “turn-on” fluorescent probe for detection of Cu2+ in living cells based on signaling mechanism of N=N isomerization. New J. Chem., 2016, 40, 6264 - 6269. DOI: 10.1039/C5NJ03649F.
65. Chunbo He, Junbin Gong, Lixia Yang, Hongwei Zhang, Shouliang Dong*,Lanxia Zhou*. The pain regulation of endokinin A/B or endokinin C/D on chimeric peptide MCRT in mice. Canadian Journal of Physiology and Pharmacology. 2016, 94: 955–960. DOI: 10.1139/cjpp-2015-0554.

2015
64. Zhongqiu Ni, Lanxia Zhou, Xu Li, Jing Zhang, Shouliang Dong*. Tetrazine-Containing Amino Acid for Peptide Modification and Live Cell Labeling. PLOS One, 2015, 10(11): e0141918. Doi: 10.1371/journal.pone.0141918.
63. Lanxia Zhou?, Qing Yang, Chunbo He, Chunnan Wei, Yinliang Yang, Shouliang Dong??. Interaction of endokinin A/B and (Mpa6)-γ2-MSH-6–12 in pain regulation in mice, Neuropeptides 2015,53, 79-84 DOI: 10.1016/j.npep.2015.06.007.

2014
62.周蘭霞,董守良,倪中秋. 一種化合物L-4-四嗪-苯丙氨酸及其制備方法和應用, 國家發明專利, 已授權: ZL201210080698.3

2013
61. 周蘭霞,達文平, 姚佳,楊銀亮,董守良, 趙麗. Opiorphin溶液構象分析. 蘭州大學學報( 醫學版). 2013. 39(3): 14-17.
60. Jianbing Jiang, Longfei Yang, Qiaoying Jin, Wude Ma, Luis Moroder, Shouliang Dong*. Site-Directed Spin Labeling of a Collagen Mimetic Peptide. Chem. Eur. J. 2013, 19, 17679-17682. DOI: 10.1002/chem.201303290.
59. 董守良,劉正錕,李曉莉,抗腫瘤藥物羅米迪司肽的關鍵中間體的合成方法,國家發明專利,已授權。專利號:ZL201110123735X.
58. 董守良,李梅興. 一種齊考諾肽的固相合成方法,國家發明專利,已授權。專利號:ZL201110139661.9.
57. Meixing Li, Lanxia Zhou, Guoning Ma, Shuo Cao, Shouliang Dong*. The cardiovascular effects of a chimeric opioid peptide based on morphiceptin and PFRTic-NH2. Peptides, 2013,39(1):89-94. Doi: 10.1016/j.peptides.2012.10.014.

2012
56. Meixing Li, Lanxia Zhou, Guoning Ma, Shouliang Dong*. Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide. Regulatory Peptides. 2012, 179, 23-28. DOI: 10.1016/j.regpep.2012.08.008.
55. Lanxia Zhou, Qiaoying Jin, Yinliang Yang, Zhengkun Liu, Xiaoli Li, Shouliang Dong*, Li Zhao**. Effects of Endokinin A/B and Endokinin C/D on the antinociception of properties of hemopressin in mice. Peptides.2012,38: 70-80. DOI: 10.1016/j.peptides.2012.08.006.
54. 陳強, 董守良, 常民. 蘭州大學生物科學專業動物生理學精品課程的建設. 中國生理學會第十屆全國生理學教學研討會論文摘要匯編, 2012. 中國生理學會第十屆全國生理學教學研討會. 2012-05-11, 中國江西南昌.
2011 
53. Qiaoying Jin, Li Lu, Yinliang Yang, Shouliang Dong*. Effects of Endokinin A/B, Endokinin C/D, and Endomorphin-1 on the regulation of mean arterial blood pressure in rats. Peptides. 32 (2011) 2428–2435. Doi: 10.1016/j.peptides.2011.10.017.
52. Bo Zhang, Junbin Gong, Yinliang Yang, Shouliang Dong*. Synthesis and diuretic activities of pseudoproline-containing analogues of the insect kinin core pentapeptide. J. Pept. Sci. 2011; 17: 601–603. DOI: 10.1002/psc.1396. 
51. Wenwei Zhang, Yuling Zeng, Shasha Wang, Qing Yang, Shouliang Dong*. Conformation analysis of a bradykinin B2 receptor antagonist, a proline rich undecapeptide. Acta Biophysica Sinica. 27(11): 937-940. DOI: 10.3724/SP.J.1260.2011.00937. 
50. Long-Fei Yang, Yang Xiao, Yun Huang, Guo-Ning Ma, Zhi-Yuan Cong and Shou-Liang Dong*. In vitro characterization for the effects of insect kinins on mouse distal colonic motility. In "Peptides: Chemistry, Biology and Pharmaceutical Sciences", Ed. by Rui Wang and Kai-Rong Wang, Proceedings of the 11th Chinese International Peptide Symposium, July 5-8, 2010, Lanzhou, China. July, 2010, 199-203.
49. Tobias E. Schrader,Thorben Cordes,Wolfgang J. Schreier,Florian O. Koller, Shou-Liang Dong, Luis Moroder, Wolfgang Zinth. Folding and Unfolding of Light-Triggered β-Hairpin Model Peptides. J. Phys. Chem. B. 2011, 115, 5219–5226. DOI: 10.1021/jp107683d.
48. Jing Wang, Li Wang, Meixing Li, Qiaoying Jin, Shouliang Dong*. Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides. Peptides. 2011, 32; 1055–1059. doi:10.1016/j.peptides.2011.01.032.
2010
47. ChunnanWei, Wenmin Huang, Xiaoting Xing and Shouliang Dong*. Dual effects of [Tyr6]-γ2-MSH(6–12) on pain perception and in vivo hyperalgesic activity of its analogues. J. Pept. Sci. 2010,16, 451-455. DOI: 10.1002/psc.1255.
46. Sha-Sha Wang, Yu-Ling Zeng, Wen-Wei Zhang, Shou-Liang Dong*. A snake venom peptidewith the contrary effect on rat stomachfundus and guinea pig ileum. Pharmazie.,2010,65: 383–385. doi: 10.1691/ph.2010.9683.
45. Yinliang Yang, Zhongqiu Ni, Shouliang Dong*, Effects of Endokinin A/B and Endokinin C/D on the antinociception of Endomorphin-1 in mice. Effects of Endokinin A/B and Endokinin C/D on the antinociception of Endomorphin-1 in mice. Peptides, 2010,31(4): 689-695. doi:10.1016/j.peptides.2009.12.022.
44. Zhiyuan Cong, Yun Huang, Longfei Yang, Dan Ye, Shouliang Dong*, Solution structure of a photo-switchable insect kinin thioxo-analog. Protein & Peptide Letters. 2010,17(3): 343-346. 
43. 魁紅,羅會穎,董守良,姚斌. 一種來源于Bispora betufina的酸性木聚糖酶基因克隆及其酶學性質研究. 中國農業科技導報,2010,12(5):109—1 15.
42. 張 波, 叢志遠, 楊銀亮, 楊龍飛, 董守良*. 昆蟲激肽的生理功能及機制. 生命的化學.,2010,30(1): 42-45.
41. Zhiyuan Cong, Longfei Yang, Ling Jiang, Dan Ye, Shouliang Dong*. Comparison of two thioxopeptide bond photoswitches in insect kinin. Chinese Chemical Letters. 2010,21(4): 476-479. doi:10.1016/j.cclet.2009.12.033.
40. Hong Kui, Huiying Luo, Pengjun Shi, Yingguo Bai, Tiezheng Yuan, Yaru Wang, Peilong Yang, Shouliang Dong, Bin Yao. Gene Cloning, Expression, and Characterization of a Thermostable Xylanase from Nesterenkonia xinjiangensis CCTCC AA001025. Appl Biochem Biotechnol. 2010,162(4):953-65. DOI: 10.1007/s12010-009-8815-5.
39. Yinliang Yang, Shouliang Dong*. Effects of Endokinin A/B and Endokinin C/D on the modulation of pain in mice. Peptides. 2010,31(1), 94-100. doi:10.1016/j.peptides.2009.10.013.
38. Guohua Lv, Shouliang Dong*. Solution Structural Investigation and Conformation-Activity Relationship of BAM8-22 by NMR and Molecular Dynamics Simulations. Bioorganic & Medicinal Chemistry Letters. 2010,20(3), 1260-1262. doi: 10.1016/j.bmcl.2009.11.110.
2009
37. Shouliang Dong, Luis Moroder, Nediljko Budisa. Protein Iodination by Click Chemistry. ChemBioChem, 2009,10, 1149-1151. DOI: 10.1002/cbic.200800816.
36. 馬國寧, 董守良*. 阿片肽樣嵌合肽. 生命的化學. 2009,29(3), 414-417.
2008
35. Huang, Y., Cong, Z., Yang, L., and Dong, S*. A photoswitchable thioxopeptide bond facilitates the conformation-activity correlation study of insect kinin, J Pept Sci 2008,14, 1062-1068.
34. Dong, S., Merkel, L., Moroder, L., and Budisa, N. Convenient syntheses of homopropargylglycine, J Pept Sci 2008, 14, 1148-1150.
33. Li Zhao, Lanxia Zhou, Baohong Zhang, Xiang Yan, Juan Li, Yali Peng, Min Chang, Shouliang Dong, Rui Wang, Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell, Pharmazie, 2008,63: 676-685.
32. Dong, S.L., Merkel, L., Musiol, H.J., Budisa, N. and Moroder, L. (2008). Advances in the stereoselective synthesis of homopropargylglycine. J. Peptide Sci. 2008,14 (8), 49-49.
31. 金蓮,劉鑫,王銳,董守良*,神經介素B 受體與拮抗劑、激動劑的分子模擬研究,化學學報,2008,2271-2278.
30. 楊丹,董守良*,人體激肽釋放酶2與前列腺癌,生命的化學,2008,731-736.
2007
29. Zinth, W., Schrader, T. E., Schreier, W. J., Koller, F. O., Cordes, T., Babitzki, G., Denschlag, R., Tavan, P., Loweneck, M., Dong, S. L., Moroder, L., and Renner, C. Ultrafast unzipping of a beta-hairpin peptide, Ultrafast Phenomena Xv 2007,88, 498-500.
28. Yu, Y., Shao, X., Cui, Y., Liu, H., Wang, C., Fan, Y., Liu, J., Dong, S., and Wang, R. Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus, Chemmedchem 2007,2, 309-317.
27. Schrader, T. E., Schreier, W. J., Cordes, T., Koller, F. O., Babitzki, G., Denschlag, R., Renner, C., Loweneckt, M., Dong, S. L., Moroder, L., Tavan, P., and Zinth, W. Light-triggered beta-hairpin folding and unfolding, Proceedings of the National Academy of Sciences of the United States of America 2007,104, 15729-15734.
26. Dong, S. L., Cadamuro, S. A., Fiorino, F., Bertsch, U., Moroder, L., and Renner, C. Copper binding and conformation of the N-terminal octarepeats of the prion protein in the presence of DPC micelles as membrane mimetic, Biopolymers 2007,88, 840-847.
25. 周蘭霞,金蓮,趙麗,孟雪琴,董守良*,ArcGIS910在苯丙酮尿癥空間分析中的應用,中國衛生統計,2007,24,604-606.
2006
24. Peng, Y. L., Chang, M., Dong, S. L., Li, W., Han, R. W., Fu, G. X., Chen, Q., and Wang, R. Novel potent agonist (pF)Phe(4),Aib(7) Aib(11),Arg(14),Lys(15) N/OFQ-NH2 and antagonist Nphe(1),(pF)Phe(4),Aib(7),Aib(11),Arg(14),Lys(15) N/OFQ-NH2 Of nociceptin/orphanin FQ receptor, Regulatory Peptides 2006,134, 75-81.
23. Loeweneck, M., Dong, S.-L., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. A photo-controlled beta-hairpin, Understanding Biology Using Peptides, 2006,36-37.
22. Dong, S. L., Loweneck, M., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. A photocontrolled beta-hairpin peptide, Chemistry-a European Journal 2006,12, 1114-1120.
2005
21. Musiol, H.-J., Dong, S., Kaiser, M., Bausinger, R., Zumbusch, A., and Moroder, L. Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins, Peptides 2004, Proceedings:BRIDGES BETWEEN DISCIPLINES, 595-596.
20. Musiol, H. J., Dong, S. L., Kaiser, M., Bausinger, R., Zurnbusch, A., Bertsch, U., and Moroder, L. Toward semisynthetic lipoproteins by convergent strategies based on click and Ligation chemistry, Chembiochem 2005,6, 625-628.
19. Musiol, H. J., Dong, S. L., Kaiser, M., Bausinger, R., Zumbusch, A., and Moroder, L. Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins, Peptides 2004, Proceedings, 595-596.
18. Loeweneck, M., Dong, S. L., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. A photo-controlled beta-hairpin, Biopolymers 2005,80, 547 (abstract).
17. Chang, M., Peng, Y. L., Dong, S. L., Han, R. W., Li, W., Yang, D. J., Chen, Q., and Wang, R. Structure-activity studies on different modifications of nociceptin/orphanin FQ: Identification of highly potent agonists and antagonists of its receptor, Regulatory Peptides 2005,130, 116-122.
16. 劉鑫,董守良*. 胸腺5肽同其受體結合的分子模型. 中國生物化學與分子生物學會第九屆會員代表大會及全國學術會議論文摘要. p86
15. 彭雅麗,常民,李威,韓仁文,付國興,董守良,王銳. (2005) 孤啡肽N末端修飾類似物的構效關系研究. 中國生物化學與分子生物學會第九屆會員代表大會及全國學術會議論文摘要. p94
14. 常民,彭雅麗,韓仁文,李威,付國興,董守良,王銳. (2005) 孤啡肽不同修飾的構效關系研究:孤啡肽受體激動劑和拮抗劑的檢定. 中國生物化學與分子生物學會第九屆會員代表大會及全國學術會議論文摘要. p145
2004
13. Shouliang Dong, Tao Wang, Bangzhi Zhang, Jie Wei, and Rui Wang. Synthesis and hypotensive activity of [Tyr1]NC(1-13)NH2, an analog of nociceptin. in Peptides, Biology and Chemistry, Eds, Yu-cang Du, You-shang Zhang, James P. Tam (2004). 189-191.
2003
12. Da, C. S., Wei, J., Dong, S. L., Xin, Z. Q., Liu, D. X., Xu, Z. Q., and Wang, R. Highly catalytic enantioselective epoxidation of enones with weak base bicarbonate and hydrogen peroxide, Synthetic Communications 2003,33, 2787-2792.
11. 李仁德,董守良,陳強. (2003) 人體及動物生理學實驗指導. 蘭州大學出版社.
2002
10. Xin, Z. Q., Da, C. S., Dong, S. L., Liu, D. X., Wei, J., and Wang, R. A novel method for the synthesis of (R)-2,2 '-dihydroxy-1,1 '-binaphthyl-3,3 '-dicarboxylic acid by asymmetric oxidative coupling of a chiral beta-naphthol derivative catalyzed by CuCl, Tetrahedron-Asymmetry 2002,13, 1937-1940.
9. Zheng-Ping Jia, Shou-Liang Dong, Xiao-Wu Yang, Bang-Zhi Zhang Xiao-Li Wang and Rui Wang. (2002) Anticancer pharmacology of actinomycin D and its analogs. In Peptides, Biology and Chemistry. Eds, James P. Tam. P198-201
2000
8. Shou-liang Dong, Rui Wang, Tao Wang and Xiao-yu Hu. The synthesis and opioid activities of nociceptin and its fragments. In Peptides, Biology and Chemistry. Eds, Xiao-yu Hu, Rui Wang, James P. Tam. P95-97
7. Rui Wang, Tao Wang, Shou-Liang Dong, Qiang Chen and Xiao-Yu Hu. Hypotensive activities of nociceptin and its fragments. In Peptides, Biology and Chemistry. Eds, Xiao-yu Hu, Rui Wang, James P. Tam. P108-109
6. 陳強; 陳勇; 陳鯉翔; 楊頂建; 董守良; 王銳; 痛穩素的合成及其對血管活性的影響, 科學通報,2000,45,2620-2625.
1999
5. 董守良,王濤,陳強,王銳. 孤啡肽及其片段的合成和構效關系. 科學通報,1999,44,1296-1300.
4. 董守良, 王 濤, 陳 強, 王 銳. 孤啡肽及其片段的合成、痛覺調節作用和對免疫功能的影響. 藥學學報,1999,34,669-672.
3. 董守良,王 濤,王 銳. 孤啡肽研究進展. 中國藥理學通報,1999,15,300-303.
1998
2. 董守良,倪京滿,王 勤,王 銳. 放線菌素D 及類似物對荷瘤小鼠生理生化影響. 蘭州大學學報,1998,34,137-138.
1997
1. WANG R, NI J, HU X, MA Y, LI X, YANG D, DONG S, YANG X, and PAN X. Synthesis and DNA-binding ability of Spl protein zinc finger domain and its peptidomimetics. Science in China, Ser. C, 1997,5, 518-523.

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