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學習經歷
■ 1994.9-1998.7,北京大學醫學部,獲理學學士學位;
■ 1998.9-2003.7,清華大學生物科學與技術系,獲理學博士學位。
工作經歷
■ 2003.9至今,蘭州大學生命科學學院,教學科研。
社會工作
研究方向
■ 重要蛋白質參與慢性炎癥疾病調控的分子機制;
■ 蛋白質的結構/功能、膜脂-蛋白相互作用。
項目成果
■ 國家自然科學基金重點項目1項,面上項目13項;
■ 國家自然科學基金優秀青年基金1項;
■ 國家自然科學基金國際合作項目2項;
■ 教育部新世紀優秀人才支持計劃2項;
■ 教育部博士點基金3項;
■ 教育部科技研究重點項目1;
■ FEI合作研究基金1項;
■ 蘭州大學人才引進專項2。
榮譽、獲獎
■ 清華大學優秀博士學位論文二等獎,2003;
■ 國家自然科學二等獎(5/5),2005;
■ 教育部新世紀優秀人才支持計劃,2007。
教學及指導研究生情況

  研究團隊教授2人、副教授2人,研究生14人。

 

發表論文及專著

[1] Zhang S.-C., Wang M.-Y., Feng J.-R., Chang Y., Ji S.-R. *, Wu Y.* (2020) Reversible promoter methylation determines fluctuating expression of acute phase proteins. eLife, 9: e51317. (IF 7.551)

[2] Zhang L., Shen Z.-Y., Wang K., Li W., Shi J.-M., Osoro E.K., Ullah N., Zhou Y., Ji S.-R. * (2019) C-reactive protein exacerbates epithelial-mesenchymal transition through Wnt/b-catenin and ERK signaling in streptozocin-induced diabetic nephropathy. FASEB Journal, 33(5): 6551-6563. (IF 5.391)

[3] Li H.-Y., Liu X.-L., Liu Y.-T., Jia Z.-K., Filep J.G., Potempa L.A., Ji S.-R. *, Wu Y.* (2019) Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein. Cardiovascular Research, 115(2): 440-452. (IF 7.014)

[4] Zhang L., Li H.-Y., Li W., Shen Z.-Y., Wang Y.-D., Ji S.-R. *, Wu Y.* (2018) An ELISA assay for quantifying monomeric C-reactive protein in plasma. Frontiers in Immunology, 9: 511. (IF 5.511)

[5] Jia Z.-K., Li H.-Y., Liang Y.-L., Potempa L.A., Ji S.-R.*, Wu Y.* (2018) Monomeric C-reactive protein binds and neutralizes RANKL-induced osteoclast differentiation. Frontiers in Immunology, 9: 234. (IF 5.51)

[6] Lv J.-M., Lv S.-Q., Liu Z.-P., Zhang J., Gao B.-X., Yao Z.-Y., Wu Y.-X., Potempa L.A., Ji S.-R.*, Long M.*, Wu Y.* (2018) Conformational folding and disulfide bonding drive distinct stages of protein structure formation. Scientific Reports, 8: 1494. (IF 4.122)

[7] Li H.-Y., Wang J., Meng F., Jia Z.-K., Su Y., Bai Q.-F., Lv L.-L., Ma F.-R., Potempa L.A., Ji S.-R.*, Wu Y.* (2016) An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein. Journal of Biological Chemistry, 291 (16): 8795-8804. (IF 4.01)

[8] Zhang L., Liu S.-H., Wright T.T., Shen Z.-Y., Li H.-Y., Zhu W., Potempa L.A., Ji S.-R.*, Szalai A.J.*, Wu Y.* (2015) C-reactive protein directly suppresses T helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. Journal of Immunology, 194 (11): 5243-5252. (IF 4.539)

[9] Su H.-X., Zhou H.-H., Wang M.-Y., Cheng J., Zhang S.-C., Hui F., Chen X-Z, Liu S.-H., Liu Q.-J., Zhu Z.-J., Hu Q.-R., Wu Y.*, Ji S.-R.* (2014) Mutations of C-reactive protein (CRP) -286 SNP, APC and p53 in colorectal cancer: implication for a CRP-Wnt crosstalk. Plos One, 9 (7): e102418. (IF 2.766)

[10] Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A., Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses. Journal of Biological Chemistry, 289 (20): 14283-14290. (IF 4.01)

[11] Wang M.-Y., Zhou H.-H., Zhang S.-C., Hui F., Zhu W., Su H.-X., Guo H.-Y., Li X.-W., Ji S.-R.*, Wu Y.* (2014) Recurrent mutations at C-reactive protein promoter SNP position -286 in human cancers. Cell Research, 24(4): 505-508. (IF 15.393)

[12] Zhang Y.-J., Shi J.-M., Bai C.-J., Wang H., Li H.-Y., Wu Y.*, Ji S.-R.* (2012) Intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay. Journal of Biological Chemistry, 287(1): 748-756. (IF 4.01)

[13] Wang M.-Y., Ji S.-R., Bai C.-J., El Kebir D., Li H.-Y., Shi J.-M., Zhu W., Costantino S., Zhou H.-H., Potempa L.A., Zhao J., Filep J.G.*, Wu Y.* (2011) A redox switch in C-reactive protein modulates activation of endothelial cells. FASEB Journal, 25(9): 3186-3196. (IF 5.595)

[14] Zhu L., Chen L., Zhou X.-M., Zhang Y.-Y., Zhang Y.-J., Zhao J., Ji S.-R., Wu J.-W.*, Wu Y.* (2011) Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure, 19(4): 515-522. (IF 4.907)

[15] Liu R.-Q., Zhou Q.-H., Ji S.-R., Zhou Q., Feng D., Wu Y., Sui S.-F.* (2010) Membrane localization of β-Amyloid 1–42 in lysosomes: a possible mechanism for lysosome labilization. Journal of Biological Chemistry, 285(26): 19986-19996. (IF 4.01)

[16] Ji S.-R., Ma L., Bai C.-J., Shi J.-M., Li H.-Y., Filep J.G., Potempa L.A., Zhao J., Wu Y.* (2009) Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft micro-domains. FASEB Journal, 23(6): 1806-1816. (IF 5.595)

[17] Ji S.-R., Wu Y.*, Zhu L., Potempa L.A., Sheng F.-L., Lu W., Zhao J. (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRPm. FASEB Journal, 21(1): 284-294. (IF 5.595)

[18] Ji S.-R., Wu Y.*, Potempa L.A., Liang Y.-H., Zhao J. (2006) Effect of modified C-reactive protein on complement activation: A possible complement regulatory role of mCRP in atherosclerotic lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(4): 935-941. (IF 6.086)

[19] Ji S.-R., Wu Y.*, Potempa L.A., Qiu Q., Zhao J. (2006) Interactions of C-reactive protein with low density lipoproteins: implications of an active role of modified C-reactive protein in atherosclerosis. International Journal of Biochemistry & Cell Biology, 384(4): 648-661. (IF 3.247)

[20] Wu Y., He Y., Bai J., Ji S.-R., Tucker W.C., Chapman E.R.*, Sui S.-F.* (2003) Visualization of synaptotagmin I oligomers assembled on lipid monolayers. Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2082-2087. (IF 9.504)

[21] Ji S.-R., Wu Y., Sui S.-F.* (2002) Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (ABeta 1-40), which may potentially inhibit the fibril formation. Journal of Biological Chemistry, 277(8): 6273-6279. (IF 4.01)

[22] Wu Y., Wang H.-W., Ji S.-R., Sui S.-F.* (2003) Two-dimensional crystallization of rabbit C-reactive protein monomeric subunits. Acta Crystallographica Section D-Biological Crystallography59(5): 922-926. (IF 3.099)

 

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