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  • 職  稱: 教授、博士生導師
  • 所在部門: 生物物理學研究所
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學習經歷

1993.9-1998.7,清華大學材料科學與工程系,獲工學學士學位;

1998.9-2003.7,清華大學生物科學與技術系,獲理學博士學位。


 

工作經歷

2003.9至今,蘭州大學生命科學學院,教學科研;

社會工作
■ 中國生物物理學會理事,2006-;

■ 中國電子顯微鏡學會理事,2008-;

■ 生物物理學報副主編,2010-;

■ Biophysics Reports副主編,2015-。

 

研究方向
■ 重要蛋白質參與慢性炎癥疾病調控的分子機制;

■ 電鏡結構生物學解析蛋白質復合體的構象變化。

 

項目成果
■ 國家自然科學基金重點項目1項,面上項目13項;
■ 國家自然科學基金優秀青年科學基金1;
■ 國家自然科學基金國際合作項目2項;
■ 霍英東青年教師基金1項;
■ 教育部新世紀優秀人才支持計劃2項;
■ 教育部博士點基金3項;
■ 教育部科技研究重點項目1;

■ FEI合作研究基金1項;

■ 中央高?;究蒲袠I務費重點項目1項;

■ 蘭州大學人才引進專項2。

 

榮譽、獲獎
■ 清華大學優秀博士學位論文一等獎,2003;
■ 教育部新世紀優秀人才支持計劃,2005;
■ 國家自然科學二等獎(3/5),2005;
■ 第四屆亞太血栓與止血大會青年研究獎,2006;
■ 第六屆甘肅青年科技獎,2007;
■ 第十三屆甘肅五四青年獎章標兵,2009;

■ 第一屆貝時璋青年生物物理學家獎,2009;

■ 第十二屆霍英東青年教師基金,2010;

■ 國家自然科學基金優秀青年基金,2012。

 

教學及指導研究生情況

  研究團隊教授2人、副教授2人,研究生14人。

 

發表論文及專著

      已發表SCI論文32篇,共獲SCI引用1100余次;代表性論文(*通訊作者):

[1] Zhang S.-C., Wang M.-Y., Feng J.-R., Chang Y., Ji S.-R. *, Wu Y.* (2020) Reversible promoter methylation determines fluctuating expression of acute phase proteins. eLife, 9: e51317. (IF 7.551)

[2] Li H.-Y., Liu X.-L., Liu Y.-T., Jia Z.-K., Filep J.G., Potempa L.A., Ji S.-R. *, Wu Y.* (2019) Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein. Cardiovascular Research, 115(2): 440-452. (IF 7.014)

[3] Zhang L., Li H.-Y., Li W., Shen Z.-Y., Wang Y.-D., Ji S.-R. *, Wu Y.* (2018) An ELISA assay for quantifying monomeric C-reactive protein in plasma. Frontiers in Immunology, 9: 511. (IF 5.511)

[4] Jia Z.-K., Li H.-Y., Liang Y.-L., Potempa L.A., Ji S.-R.*, Wu Y.* (2018) Monomeric C-reactive protein binds and neutralizes RANKL-induced osteoclast differentiation. Frontiers in Immunology, 9: 234. (IF 5.51)

[5] Lv J.-M., Lv S.-Q., Liu Z.-P., Zhang J., Gao B.-X., Yao Z.-Y., Wu Y.-X., Potempa L.A., Ji S.-R.*, Long M.*, Wu Y.* (2018) Conformational folding and disulfide bonding drive distinct stages of protein structure formation. Scientific Reports, 8: 1494. (IF 4.122)

[6] Li Q.-Y., Li H.-Y., Fu G., Yu F.*, Wu Y.*, Zhao M.-H. (2017)  Autoantibodies against C-reactive protein influences complement activation and clinical course in lupus nephritisJournal of the American Society of Nephrology28 (10): 3044-3054. (IF 8.655)

[7] Li H.-Y., Wang J., Meng F., Jia Z.-K., Su Y., Bai Q.-F., Lv L.-L., Ma F.-R., Potempa L.A., Ji S.-R.*, Wu Y.* (2016) An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein. Journal of Biological Chemistry, 291 (16): 8795-8804. (IF 4.01)

[8] Ouyang Y., Zhu L.*, Li Y.-F., Guo M.-M., Liu Y., Cheng J., Zhao J., Wu Y.* (2016) Architectural plasticity of AMPK revealed by electron microscopy and X-ray crystallography. Scientific Reports, 6:24191. (IF 4.122)

[9] Zhang L., Liu S.-H., Wright T.T., Shen Z.-Y., Li H.-Y., Zhu W., Potempa L.A., Ji S.-R.*, Szalai A.J.*, Wu Y.* (2015) C-reactive protein directly suppresses T helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. Journal of Immunology, 194 (11): 5243-5252. (IF 4.539)

[10] Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A., Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses. Journal of Biological Chemistry, 289 (20): 14283-14290. (IF 4.01)

[11] Wang M.-Y., Zhou H.-H., Zhang S.-C., Hui F., Zhu W., Su H.-X., Guo H.-Y., Li X.-W., Ji S.-R.*, Wu Y.* (2014) Recurrent mutations at C-reactive protein promoter SNP position -286 in human cancers. Cell Research, 24(4): 505-508. (IF 15.393)

[12] Zhang Y.-J., Shi J.-M., Bai C.-J., Wang H., Li H.-Y., Wu Y.*, Ji S.-R.* (2012) Intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay. Journal of Biological Chemistry, 287(1): 748-756. (IF 4.01)

[13] El Kebir D., Zhang Y., Potempa L.A., Wu Y., Fournier A., Filep J.G.* (2011) C-reactive protein-derived peptide 201–206 inhibits neutrophil adhesion to endothelial cells and platelets through CD32. Journal of Leukocyte Biology, 90(6): 1167-1175. (IF 4.224)

[14] Wang M.-Y., Ji S.-R., Bai C.-J., El Kebir D., Li H.-Y., Shi J.-M., Zhu W., Costantino S., Zhou H.-H., Potempa L.A., Zhao J., Filep J.G.*, Wu Y.* (2011) A redox switch in C-reactive protein modulates activation of endothelial cells. FASEB Journal, 25(9): 3186-3196. (IF 5.595)

[15] Zhu L., Chen L., Zhou X.-M., Zhang Y.-Y., Zhang Y.-J., Zhao J., Ji S.-R., Wu J.-W.*, Wu Y.* (2011) Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure, 19(4): 515-522. (IF 4.907)

[16] Wang B.-B., Yu C.-H., Xi Y.-B., Cai H.-C., Wang J., Zhou S.-R., Zhou S.-Y., Wu Y., Yan Y.-B.*, Ma X.*, Xie L.-X.* (2011) A novel CRYGD mutation (p.Trp43Arg) causing autosomal dominant congenital cataract in a Chinese family. Human Mutation, 32(1): E1939-E1947. (IF 5.359)

[17] Liu R.-Q., Zhou Q.-H., Ji S.-R., Zhou Q., Feng D., Wu Y., Sui S.-F.* (2010) Membrane localization of β-Amyloid 1–42 in lysosomes: a possible mechanism for lysosome labilization. Journal of Biological Chemistry, 285(26): 19986-19996. (IF 4.01)

[18] Ji S.-R., Ma L., Bai C.-J., Shi J.-M., Li H.-Y., Filep J.G., Potempa L.A., Zhao J., Wu Y.* (2009) Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft micro-domains. FASEB Journal, 23(6): 1806-1816. (IF 5.595)

[19] Shen Q.T., Bai X.C., Chang L.F., Wu Y., Wang H.W., Sui S.-F.* (2009) Bowl-shaped oligomeric structures on membranes as DegP’s new functional forms in protein quality control. Proceedings of the National Academy of Sciences of the United States of America, 106(12): 4858-4863. (IF 9.504)

[20] Jiang J., Zhang X., Chen Y., Wu Y., Zhou Z.H., Chang Z., Sui S.-F.* (2008) Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. Proceedings of the National Academy of Sciences of the United States of America, 105(33): 11939-11944. (IF 9.504)

[21] Ji S.-R., Wu Y.*, Zhu L., Potempa L.A., Sheng F.-L., Lu W., Zhao J. (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRPm. FASEB Journal, 21(1): 284-294. (IF 5.595)

[22] Ji S.-R., Wu Y.*, Potempa L.A., Liang Y.-H., Zhao J. (2006) Effect of modified C-reactive protein on complement activation: A possible complement regulatory role of mCRP in atherosclerotic lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(4): 935-941. (IF 6.086)

[23] Ji S.-R., Wu Y.*, Potempa L.A., Qiu Q., Zhao J. (2006) Interactions of C-reactive protein with low density lipoproteins: implications of an active role of modified C-reactive protein in atherosclerosis. International Journal of Biochemistry & Cell Biology, 384(4): 648-661. (IF 3.247)

[24] Wu Y., He Y., Bai J., Ji S.-R., Tucker W.C., Chapman E.R.*, Sui S.-F.* (2003) Visualization of synaptotagmin I oligomers assembled on lipid monolayers. Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2082-2087. (IF 9.504)

[25] Ji S.-R., Wu Y., Sui S.-F.* (2002) Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (ABeta 1-40), which may potentially inhibit the fibril formation. Journal of Biological Chemistry, 277(8): 6273-6279. (IF 4.01)

[26] Wu Y., Wang H.-W., Ji S.-R., Sui S.-F.* (2003) Two-dimensional crystallization of rabbit C-reactive protein monomeric subunits. Acta Crystallographica Section D-Biological Crystallography, 59(5): 922-926. (IF 3.099)

 

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